Happy New Year

Best Wishes and Good Thoughts in 2011 from the Iseehear Team !!!

Coming Soon SoftMouseDB version 2 Pre-Launch Promotion

SoftMouseDB version 2 Mouse Colony Software Database Pre-Launch Promotion Coming Soon http://www.30dayfreetrialpromo.net

Follow Iseehear Rewards on Twitter http://twitter.com/IseehearRewards

SoftMouseDB Mouse Colony Software - Autumn 2010 Update

SoftMouseDB Mouse Colony Software usability improvements

The SoftMouse Development Team has released a number of new features and usability improvements to the SoftMouseDB Mouse Colony Software application over the past several months.

The new features and improvements stemmed from your suggestions and feedback, which allowed us to enhance the usability of SoftMouseDB based on your needs and requirements.

As you are aware, we are continuously trying to find new ways to improve the usability of SoftMouseDB Mouse Colony Software application and we are grateful for your continued feedback.

That said, there are more beneficial new releases and usability improvements planned for this Autumn and Winter!

You can keep up to date on new releases via the Iseehear Support Desk blog posts  and the Iseehear Support Desk Twitter account @IseehearSupport.

We are interested in and welcome of any feedback that you may have regarding the continued enhancement of SoftMouseDB.

Thank you for your support!

Regards,
SoftMouseDB Development Team

Iseehear Inc.  BioMedical Software Development and Database Services

SoftMouseDB  Mouse Colony Management Software & Relational Database

30 DAY FREE TRIAL  Mouse Colony Management Software Free Demonstration and Evaluation

Iseehear Early Adopter Program  Quality Assurance Process & Performance Testing

Family List Filter Update Released for SoftMouseDB

Notice for SoftMouseDB Subscribers

On Saturday evening August 21 we updated the Family List Filter on SoftMouseDB located at www.streamcell.com

Specifically, you will notice that you can now filter your Family List by multiple Mouselines at one time. 

Subscribers: Please see your email for brief description on:

• How to use the Family List Filter

 

Please do not hesitate to let us know your thoughts!

 

Thank you for your support

Regards,
Kelly Rodriques,
Iseehear Support Desk

New Features Released for SoftMouseDB

The Mouse Group Edit function has been successfully deployed at www.streamcell.com

Subscribers: Please see your email for brief descriptions on:

• How to use the Group Edit function
• How the "Apply" buttons work
• A Few Tips to keep in mind

Click here to find out more about SofMouseDB and how Iseehear can help you manage your research and experimental data management needs and requirements.

New Features Released for SoftMouseDB

The planned SoftMouseDB functionality Upgrade was successfully deployed into the application.
When you login to your account, you will notice the changes and additions to all of the Edit Pages.

About: SoftMouseDB - Transgenic and Knockout Mouse / Mice Breeding and Colony Maintenance Record-Keeping System. 

Click here to find out more about SofMouseDB and how Iseehear can help you manage your research and experimental data management needs and requirements.

SoftMouseDB 30 DAY FREE Trial Presentation

Transgenic Knockout mouse colony breeding relational database software.

30 DAY FREE Trial Presentation. 

Reduce your labs mouse breeding colony operating costs. 

Improve data management productivity with SoftMouseDB. 

View the presentation https://www.30dayfreetrialpromo.com/eap/about_eap.jsp#presentation1

Create a 30 DAY FREE TRIAL account https://www.30dayfreetrialpromo.com/registration.do

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 About: SoftMouseDB - Transgenic and Knockout Mouse / Mice Breeding and Colony Maintenance Record-Keeping System.

The Iseehear 30 DAY FREE TRIAL & Promotions website allows life science researchers to evaluate the usefulness and benefits of Iseehear's biomedical database and software offerings prior to committing to an annual subscription.

30 DAY FREE TRIAL & Promotions  https://www.30dayfreetrialpromo.com 

Mouse Study, Researchers Discover New Mechanism for Clearing Blockages from Smallest Blood Vessels

Embargoed for Release
Wednesday, May 26, 2010
1 p.m., EDT 

Article Source link

Researchers at Northwestern University Feinberg School of Medicine have identified in mice a previously unknown protective mechanism by which the smallest blood vessels remove blood clots and other blockages from the brain. The findings provide insights into mechanisms that may be involved in age-related cognitive decline, Alzheimer’s disease and recovery from stroke.

These findings were described in the May 27 issue of Nature by Jaime Grutzendler, M.D., and colleagues. The study was supported by the National Institute on Aging (NIA), part of the National Institutes of Health.

Uninterrupted blood flow is critical for brain function, and the brain has developed various mechanisms to maintain it. Blockages in the smallest blood vessels can be cleared by processes that disintegrate or wash them out. However, not all blockages are cleared completely. Persistent blockage can reduce or stop blood flow, limiting the supply of oxygen and nutrients to the surrounding tissue and nerve cells. This, in turn, can lead to impaired communications between nerve cells and ultimately cell death.

The researchers used a newly developed imaging technique that can view the smallest blood vessels, known as microvessels, in the brains of living mice. They found that two to seven days after a blockage in brain microvessels, the cells lining the blood vessel wall engulf the remaining portion of the blockage, encapsulate it, seal it off from the interior of the blood vessel and finally expel the blocking material outside of the vessel. As a result of this process, blood flow is restored to the affected area. (See graphic below.) 

Time-lapse images of a blood vessel in a mouse brain. On Day 1, the interior membrane of the blood vessel starts to extend around the orange cholesterol blockage (arrow). By Day 3, the membrane has surrounded the cholesterol and created a pathway to the outside of the blood vessel (arrowhead). On Day 5, the blockage has moved outside the blood vessel, which is now unimpeded. (asterisk). Image courtesy of C.K. Lam, et al., Nature, 2010. 

"These are intriguing findings," said NIA Director Richard J. Hodes, M.D. "They open new avenues of basic research that may increase our understanding of how microvessels are maintained in the brain and throughout the body."

The research team demonstrated that this complex protective mechanism involves the activity of an enzyme, matrix metalloprotease 2/9, which breaks down large proteins and is known to play a role in blood vessel development and in stroke.

The researchers also found that the ability to move the blockage out of the blood vessel diminished with age. Young mice (age 4 months) were able to clear blockages more quickly and thoroughly than older mice (age 22 months). The incomplete removal of blockages in the brains of older mice led to a prolonged shortage of oxygen to the surrounding nerve cells and damaged the connections between nerve cells in the vicinity of the obstructed blood vessels.

"The reduced efficiency of this protective mechanism in the older brain and its effect on the function of nerve cells in the brain may significantly contribute to age-related cognitive decline," said Suzana Petanceska, Ph.D., of the Neurobiology of Aging Branch in NIA's Division of Neuroscience, which funded the research. "This may also be part of the mechanism by which vascular risk factors such as high blood pressure and diabetes increase the risk of Alzheimer's disease with age."

The NIA leads the federal effort supporting and conducting research on aging and the medical, social and behavioral issues of older people. For more information on research and aging, go to www.nia.nih.gov.

End of article

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 About: SoftMouseDB - Transgenic and Knockout Mouse / Mice Breeding and Colony Maintenance Record-Keeping System.

The Iseehear 30 DAY FREE TRIAL & Promotions website allows life science researchers to evaluate the usefulness and benefits of Iseehear's biomedical database and software offerings prior to committing to an annual subscription.

The first application to be hosted on 30 DAY FREE TRIAL & Promotions is SoftMouseDB - Transgenic and Knockout Mouse / Mice Breeding and Colony Maintenance Record-Keeping System.

Click here to find out more about SofMouseDB and how Iseehear can help you manage your research and experimental data management needs and requirements.

30 DAY FREE TRIAL & Promotions  https://www.30dayfreetrialpromo.com

SoftMouseDB v2 Notice: To all Early Adopter Program Users

Limited testing of selected SoftMouseDB v2 features will begin on May 1, 2010.
Information will be sent to your email accounts in the coming days.
If you have any questions, please do not hesitate to contact me at any time. Thank you!

Kelly

Tip #3 Iseehear Research Continuity Tools

Iseehear Research Continuity Tools located on SoftMouseDB will allow you to have quick offline digital or hard copy access to your records at all times.

 

Please take advantage of the Research Continuity Tools built into the SoftMouseDB application, including:

1. Print to PDF which is a button located on every page of SoftMouseDB - you can select the records you want  to print and simply click the "Print" button
2. Export to Spreadsheet which is located as a menu item in the Orange Question mark at the top right of the interface - you can export all of your records to a local spreadsheet

About SoftMouseDB

The SoftMouseDB mouse colony management software has options for tracking mice, cages, weaning, breeding and transgenic and knockout mouse / mice colonies.

Improve productivity, manage daily operations, establish accurate inventories of your mouse colonies and reduce your lab's mouse, breeding and research operating costs with SoftMouseDB.

Join the SoftMouseDB community and discover the benefits of using a relational database management system to Manage Your Mouse Colony Research.

Sign up for the 30 DAY FREE TRIAL at www.streamcell.net

Transgenic Mouse Breeding & Colony Management Database Software;

KnockOut Mouse , KnockOut Mice, Electronic Laboratory Notebook (ELN), Mouse Colony Management Software 

SoftMouseDB ** Important Message** Update # 3

Access to SoftMouseDB Enterprise is fully operational at https://www.streamcell.com

Subscribers please see your email for details.

We provide updates to our subscribers via these Iseehear Support Desk Channels:
Email: support@iseehear.com
Notice Board: Located on the left side of the Login page
Support Desk Blog: http://iseehearsupportdesk.blogspot.com/
Support Desk on Twitter: http://twitter.com/IseehearSupport

Please do not hesitate to contact us at any time if you need assistance or have any questions.

Thank you for your support

SoftMouseDB ** Important Message** Update # 2 - System Maintenance – Sunday February 28, 2010

Purpose for the System Maintenance:
To restore access to SoftMouseDB Enterprise on www.streamcell.com

SoftMouseDB Enterprise service access will be unavailable as follows:
Date: Sunday February 28, 2010
Time: 2:00 AM EST  to  6:00 AM EST

SoftMouseDB Enterprise service access will resume as follows:
URL: www.streamcell.com
Date: Sunday February 28, 2010
Time: 6:00 AM EST

Please Note:
The access to SoftMouseDB Enterprise on the Iseehear Research Continuity Environment will be closed once the SoftMouseDB Enterprise service has been restored on www.streamcell.com

(All times are Eastern Standard Time Toronto, Canada - Please click the individual Time designations to find the corresponding time in your location) 

We will continue to provide updates to our subscribers via these Iseehear Support Desk accounts:
Email: support@iseehear.com
Notice Board: Located on the left side of the Login page
Support Desk Blog: http://iseehearsupportdesk.blogspot.com/
Support Desk on Twitter: http://twitter.com/IseehearSupport

Please do not hesitate to contact us at any time if you have any questions.

Thank you for your continued support.  

SoftMouseDB **IMPORTANT MESSAGE** Update # 1

SoftMouseDB at www.streamcell.com is down. We are working on restoring service now.

Current subscribers to the SoftMouseDB Enterprise: Please check your email for important information and instructions.

Incident Summary: On Sunday evening February 21 during a routine test of the SoftMouseDB Enterprise service we discovered that the SoftMouseDB application was not operating up to specifications. A decision was made to take the primary service offline in order investigate and resolve the issue. In the interim the Iseehear Research Continuity Environment was activated to provide service to our subscribers.

We will continue to provide updates to our subscribers via these Iseehear Support Desk accounts:
Email: support@iseehear.com
Notice Board: Located on the left side of the Login page
Support Desk Blog: http://iseehearsupportdesk.blogspot.com/
Support Desk on Twitter: http://twitter.com/IseehearSupport

We sincerely apologize for the inconvenience.

Regards,
Kelly Rodriques,
Iseehear Support Desk
Iseehear Network Operations

Hello Subscriber **IMPORTANT MESSAGE**

SoftMouseDB at www.streamcell.com is down.
We are working on restoring service now.
We sincerely apologize for the inconvenience. 
We will keep you updated at http://twitter.com/IseehearSupport

Regards,
Iseehear Network Operations

NEW features SoftMouseDB Enterprise v 1.0.3

NEW features have been added to SoftMouseDB Enterprise v 1.0.3

Current subscribers to the SoftMouseDB Enterprise:  Please check your email for details on the new features.

For New subscribers there is a FREE 30 DAY TRIAL of  SoftMouseDB Enterprise --Transgenic Mouse Breeding relational database and Colony Management software -- at  www.streamcell.com 

SoftMouseDB - System Maintenance and Application Upgrade

1- IMPORTANT: System Maintenance and Application Upgrade - SoftMouseDB Application access will be temporarily unavailable on Saturday January 30, 2010 from 8:00 PM to Sunday January 31 12:05 AM (All times are Eastern Standard Time Toronto, Canada) (Click the individual Time designations to find the corresponding time in your location)

2- A NEW version of SoftMouseDB will be available on Sunday January 31, 2010. Details on the new features will be sent to your email account on Monday February 1, 2010.

3- To learn more about Scheduled Upgrades and System Maintenance Procedures please click here

4- To view future Scheduled Upgrades and System Maintenance dates please click here

Thank you for your support.
The Iseehear SoftMouseDB Team
Transgenic Mouse Breeding & Colony Management Database Software; Electronic Laboratory Notebook (ELN)

SoftMouseDB - Updates and New Features in the Coming Weeks.

1- Iseehear will be releasing SoftMouseDB updates and new features in the coming weeks.

2- If you would like to Register for a 30 DAY FREE Trial of SoftMouseDB please visit www.streamcell.com

3- Please remember to send us your requirements if there are additional features that you would like to have added to SoftMouseDB. Please use the Orange Feedback and Support buttons at the top right of the SoftMouseDB interface to communicate directly with the Iseehear team.
 
Thank you for your support.
The Iseehear SoftMouseDB Team
Transgenic Mouse Breeding & Colony Management Database Software; Electronic Laboratory Notebook (ELN)